New! Postdoctoral Fellow Positions in Chromatin Biology

The SGC has recently launched a public-private partnership to generate small molecule "chemical probes" for use in research on epigenetic signalling. Using the SGC's strength in making active recombinant human proteins, we will develop inhibitors of three important protein families involved in epigenetic signalling: the Histone Methyltransferases, Histone Acetyltransferases and members of the "Royal Family" of chromatin-interacting domains. We aim to develop 15 chemical probes with pre-defined potencies, selectivities and cellular activities for use in biological research. The chemical probes will be made available without restrictions on use and the associated data will be placed into the public domain via publications and deposition into public databases. We are actively working industrial and academic medicinal chemists and with local and international investigators who will use our probes to accelerate research on the role of epigenetic signalling in human biology and diseases, such as cancer, inflammation, mental illness and stem cell biology.

The Toronto site of the SGC seeks adventurous, motivated molecular and cell biologists to work in collaboration with protein biochemists, structural biologists, and medicinal chemists to develop cellular assays to help develop and characterize chemical probes.

Postdoctoral Fellow: 0-2 years post-PhD, with experience in chromatin molecular and cell biology.

Interested Candidates please send CV and statement of interest to Cheryl Arrowsmith carrow@uhnres.utoronto.ca with the term "EpiG probes" in the subject line.

Ongoing! Post-doctoral Scientist, Crystallography - The SGC seeks enthusiastic PhD scientists with experience in protein biochemistry, x-ray crystallography and/or structural biology. The SGC offer fellows the opportunity to learn state of the art methods in eukaryote protein expression, htp crystallization and structure determination. The major duties for successful candidates will include one or more of the following; protein expression & purification, crystallization, data collection (home and synchrotron), structure determination, and structure deposition to the PDB. The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from viisible minority group members, women, Aboriginal persons, persons with disabilities, members of sexual minority groups, and other who may contribute to the further diversification of ideas. All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority.

Interested candidates are encouraged to submit their CVs and a brief statement of research interests to HR.sgc@utoronto.ca. In the subject header, clearly indicate the position you are applying for.